Lasix - a diuretic quick action, based on their chemical structure is derived from sulfonamide. To the reader will immediately understand what is at stake - an original drug furosemide from "Sanofi-aventis' global pharmaceutical corporation. diuretic effect of Lasix mechanism is inhibition of reabsorption (reuptake) of sodium and chlorine ions in the renal tubules. Thus, the body more readily parted from sodium (chlorine, too, but the former has much greater clinical value), resulting in a cascade of secondary potentiated effects: an increase in urine volume, increased excretion of potassium ions, calcium and magnesium. It is characteristic that the re-admission of its diuretic Lasix activity continues unabated. In patients with chronic heart failure drug as soon as possible reduces preload (this is due to vasodilation of the venous bed), "stravlyaet pairs" (read: reduces pressure) in the pulmonary artery and the left ventricular chamber. Elan its pharmacological effect, as experts believe, Lasix is obliged to prostaglandins, so a prerequisite to the preparation turned "to the fullest" is the normal functioning of the prostaglandin system, as well as adequate work of the kidneys. Lasix has an antihypertensive action, based on the enhanced sodium excretion from the body, increased diuresis and the related decrease in circulating blood volume, reducing the sensitivity of smooth muscle walls of blood vessels to vasoconstrictor effect. In the latter case it is, first of all, catecholamines: due to increased sodium excretion Lasix softens increased (which is characteristic of high blood pressure) vascular response to these potent vasoconstrictor. As shown in clinical studies in healthy volunteers, and the diuretic effect of Lasix salureticheskim observed while taking the drug in the range from 10 to 100 mg. More about Furosemide.
After parenteral administration of 20 mg, the diuretic effect begins to show after 15 minutes and lasted for about 3 hours.
The manufacturer has mastered production of two Lasix dosage forms: tablets and solution for intravenous and intramuscular administration. Lasix treatment is preferably carried out using the lowest effective dose of the drug. It should be noted dose dependency of the therapeutic effect of the drug, as well as mention that Lasix is very high pharmacological "ceiling" (it increases the activity of a wide range of doses). Although two paths claimed parenteral administration (intramuscular and intravenous), the second of which is used only in exceptional cases, when there is no possibility to introduce a solution into a vein or consume the tablet. Similarly relates intravenous and oral method of administration: injection is carried out only in situations where for some reason can not receive the drug inside, there are violations of furosemide absorption in the small intestine or the need to obtain extremely rapid therapeutic effect. When using the injection form of Lasix is recommended as the patient can be transferred quickly to the tablet form. Before the start of drug therapy is necessary to exclude the presence of pronounced disorders of urodynamics (outflow of urine). During treatment desired control over blood concentrations of sodium, potassium, and creatinine. Particularly careful monitoring should be performed for patients prone to violations of water-electrolyte balance (the cause of which can serve as diarrhea, vomiting or an intense hyperhidrosis). During the course of medication is recommended to enrich the diet with potassium, which is administered in the menu foods such as lean meat, tomatoes, cauliflower, spinach, potatoes, bananas, dried fruits, etc. Sometimes, depending on the situation may require reception potassium preparations.
More: RxList - Lasix drug.